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表面涂層對用于骨組織工程的多孔鎂支架的影響
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1.北京科技大學 新材料技術研究院,北京 100083;2.廣東工業(yè)大學,廣東 廣州 510006;3.季華實驗室,廣東 佛山 528299

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基金項目:

季華實驗室(Grant No. X190061UZ190)和廣東省科技項目(Grant No. 2016B090914001)


Effect of Surface Coating on Porous Mg Scaffolds for Bone Engineering
Author:
Affiliation:

1.Institute for Advanced Materials & Technology, University of Science and Technology Beijing, Beijing 100083, China;2.Guangdong Univer-sity of Technology, Guangzhou 510006, China;3.Jihua Laboratory, Foshan 528299, China

Fund Project:

Jihua Laboratory Project (X190061UZ190); Science and Technology Projects of Guangdong Province (2016B090914001)

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    摘要:

    多孔鎂(Mg)支架有利于生物植入,但是由于Mg的高活性,植入后降解速度過快,不利于新骨的形成。為了有效地控制鎂支架的降解,研究了3種不同表面涂層對多孔鎂支架的影響。通過能量色散光譜儀(EDS),X射線衍射(XRD)和紅外傅里葉變換光譜(FTIR)證實支架表面的組成為純Mg,氧化鎂(MgO),磷酸氫鈣(DCPD)和硬脂酸(SA)。結果表明,從表面形貌可以看出,SA涂層更光滑,更致密。模擬體液(SBF)的體外降解實驗表明,與未涂覆的Mg支架相比,表面涂層可以有效地減慢支架的降解,并且DCPD涂層和SA涂層優(yōu)于MgO涂層。在第15周時,浸泡在SBF中的DCPD和SA涂層支架的降解率為70%,這可以為新骨的生長提供一定的時間。

    Abstract:

    Porous magnesium (Mg) scaffolds are beneficial to biological implantation, but because of the high activity of Mg, the degradation rate after implantation is too fast, which is not conducive to the formation of new bone. In order to effectively control the degradation of Mg scaffolds, three different surface coatings, magnesium oxide (MgO), calcium hydrogen phosphate (DCPD) and stearic acid (SA) on the porous Mg scaffolds was prepared and their effects on the scaffolds were investigated. The surface composition of the uncoated scaffold and the coatings was confirmed to be pure Mg, MgO, DCPD and SA by energy dispersive spectrometer (EDS), X-ray diffraction (XRD) and Fourier transforms infrared spectra (FTIR). The results show that SA coating is smoother and more compact in surface morphology. In vitro degradation in simulated body fluid (SBF) indicates that surface coatings can effectively slow down the scaffold degradation, while DCPD coating and SA coating are better than MgO coating in resisting the degradation. The degradation rate of the scaffolds with DCPD and SA coating soaked in SBF is 70% at the 15th week, which provides a certain period of time for the growth of new bone.

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林濤,靳瀏平,李文媛,邵慧萍,袁佳昀,鄧欣.表面涂層對用于骨組織工程的多孔鎂支架的影響[J].稀有金屬材料與工程,2021,50(10):3520~3526.[Lin Tao, Jin Liuping, Li Wenyuan, Shao Huiping, Yuan Jiayun, Deng Xin. Effect of Surface Coating on Porous Mg Scaffolds for Bone Engineering[J]. Rare Metal Materials and Engineering,2021,50(10):3520~3526.]
DOI:10.12442/j. issn.1002-185X. E20200041

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  • 收稿日期:2020-08-26
  • 最后修改日期:2020-09-26
  • 錄用日期:2020-10-23
  • 在線發(fā)布日期: 2021-10-28
  • 出版日期: 2021-10-25