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具有載藥活性的聚-β-羥基丁酸酯涂層對(duì)WE鎂合金在模擬體液中的降解行為和細(xì)胞功能的影響
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1.School of Chemistry and Chemical Engineering, Chongqing University of Technology;2.重慶理工大學(xué)化學(xué)化工學(xué)院

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Effects of drug-contained Poly-β-hydroxybutyrate coating on degradation behavior of WE magnesium alloys in simulated body fluid and cell function
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1.重慶理工大學(xué)化學(xué)化工學(xué)院;2.School of Chemistry and Chemical Engineering, Chongqing University of Technology

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    摘要:

    鎂及其合金具有作為臨床醫(yī)學(xué)中的可吸收生物材料的巨大潛力，但鎂合金的腐蝕速率過(guò)快，可能導(dǎo)致植入物失效。本研究使用層層自組裝技術(shù)在WE鎂合金表面構(gòu)建具有藥物的聚-β-羥基丁酸酯（PHB）涂層。研究了鎂合金與藥物涂層在模擬體液（SBF）中的腐蝕行為。通過(guò)觀察降解過(guò)程中溶液濃度和微觀結(jié)構(gòu)的變化。從細(xì)胞遷移，細(xì)胞毒性和細(xì)胞凋亡來(lái)研究藥物涂層對(duì)組織細(xì)胞的影響。結(jié)果表明，具有生物活性藥物涂層有效降低了樣品在SBF中的腐蝕速率，細(xì)胞毒性，凋亡，促進(jìn)了細(xì)胞的遷移。

    Abstract:

    Magnesium and its alloys have great potential as absorbable biomaterials in clinical medicine, but their rapid corrosion might lead to implant failure. The purpose of this study was to prepare Poly-β-hydroxybutyrate (PHB) coating with drug on the surface of WE magnesium alloys using layer-by-layer self-assembly technique. The corrosion behavior of magnesium alloys with drug coating in simulated body fluid (SBF) was studied. The solution concentration and microstructure change during degradation process were observed. The effects of drug coating on tissue cells were investigated by cell migration, cytotoxicity and apoptosis. The results showed that the bioactive drug coating effectively reduced the corrosion rate of the samples in SBF, cytotoxicity, apoptosis, and promoted the migration of the cells.

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全亮,葛淑萍,賈東煜,劉陳宇,王貴學(xué),尹鐵英.具有載藥活性的聚-β-羥基丁酸酯涂層對(duì)WE鎂合金在模擬體液中的降解行為和細(xì)胞功能的影響[J].稀有金屬材料與工程,2020,49(8):2599~2606.[Quan liang, Ge Shuping, Jia Dongyu, Liu Chenyu, Wang Guixue, Yin Tieying. Effects of drug-contained Poly-β-hydroxybutyrate coating on degradation behavior of WE magnesium alloys in simulated body fluid and cell function[J]. Rare Metal Materials and Engineering,2020,49(8):2599~2606.]
DOI：10.12442/j. issn.1002-185X. E20190077

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  • 收稿日期:2019-05-07
  • 最后修改日期:2019-07-29
  • 錄用日期:2019-08-21
  • 在線發(fā)布日期: 2020-09-27
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