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陽(yáng)極氧化鋁納米結(jié)構(gòu)協(xié)同當(dāng)歸多糖對(duì)乳腺癌細(xì)胞生長(zhǎng)的影響規(guī)律研究
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陜西師范大學(xué) 物理學(xué)與信息技術(shù)學(xué)院

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國(guó)家自然科學(xué)基金項(xiàng)目（面上項(xiàng)目，重點(diǎn)項(xiàng)目，重大項(xiàng)目）21965030；陜西省重點(diǎn)研發(fā)計(jì)劃2023—YBGY—477


Effect of Anodic Aluminum Oxide Modified by Angelica sinensis Polysaccharide on the Growth of Breast Cancer Cells
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School of the Physics and Information Technology, Shaanxi Normal University

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    摘要:

    系統(tǒng)的研究了不同周期的納米凹坑和納米柱孔氧化鋁膜表面直接修飾當(dāng)歸多糖（ASP）或通過(guò)γ-氨丙基三乙氧基硅烷（KH550）共價(jià)連接修飾ASP后，乳腺癌細(xì)胞MDA-MB-231在其表面生長(zhǎng)的細(xì)胞形態(tài)和活性規(guī)律。研究發(fā)現(xiàn)，當(dāng)歸多糖直接修飾納米凹坑和納米柱孔結(jié)構(gòu)能夠有效抑制乳腺癌細(xì)胞的活性，對(duì)細(xì)胞形態(tài)影響較小。但納米凹坑結(jié)構(gòu)的細(xì)胞活性抑制效果優(yōu)于納米柱孔結(jié)構(gòu)，納米凹坑在300 nm周期時(shí)具有最優(yōu)的細(xì)胞活性抑制效果，抑制率為27.7%。用KH550共價(jià)修飾ASP的納米凹坑和納米柱孔結(jié)構(gòu)對(duì)細(xì)胞活性的抑制效果要優(yōu)于直接修飾ASP時(shí)的抑制效果，細(xì)胞形態(tài)也發(fā)生了明顯的變化，胞體周?chē)纱罅堪鍫顐巫?。納米凹坑結(jié)構(gòu)上的細(xì)胞活性抑制效果要優(yōu)于納米柱孔結(jié)構(gòu)，納米凹坑在300 nm周期時(shí)抑制效果最佳，抑制率為28.2%。該結(jié)果對(duì)于藥物的設(shè)計(jì)以及輸運(yùn)具有一定的指導(dǎo)作用。

    Abstract:

    The surface of nanodent and nanopore structured alumina membranes with different periods were directly modified by Angelica sinensis polysaccharide (ASP) or covalently modified by ASP via γ-aminopropyl triethoxysilane (KH550). After that, the morphology and cell viability of breast cancer cells MDA-MB-231 grew on the modified nanostructured surfaces were systematically studied. It was found that nanodent and nanopore structure directly modified by ASP could effectively inhibit the viability of breast cancer cells, and had little effect on cell morphology. However, the inhibitory effect of nanodent structure on cell viability was superior to that of nanopore structure. Nanodent structure with period of 300 nm had the best inhibitory effect on cell viability, and the inhibitory rate is 27.7%. The nanodent and nanopore structures covalently modified by ASP via KH550 had a better inhibitory effect on cell viability than that directly modified ASP, and the cell morphology changed obviously. A large number of lamellipodia were generated around the cell body. However, the inhibition effect of the nanodent structure on cell viability was better than that of the nanopore structure. Nanodent structure with period of 300 nm had the best inhibitory effect, and the inhibition rate is 28.2%. These results have a certain function for the design and delivery of drugs.

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張智穎,梁瑞清,陳俊霖,梅晁源,李娟,孫潤(rùn)廣.陽(yáng)極氧化鋁納米結(jié)構(gòu)協(xié)同當(dāng)歸多糖對(duì)乳腺癌細(xì)胞生長(zhǎng)的影響規(guī)律研究[J].稀有金屬材料與工程,2023,52(11):3947~3953.[zhang zhi ying, liang rui qing, chen jun lin, mei chao yuan, li juan, sun run guang. Effect of Anodic Aluminum Oxide Modified by Angelica sinensis Polysaccharide on the Growth of Breast Cancer Cells[J]. Rare Metal Materials and Engineering,2023,52(11):3947~3953.]
DOI：10.12442/j. issn.1002-185X.20230384

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  • 收稿日期:2023-06-16
  • 最后修改日期:2023-07-27
  • 錄用日期:2023-07-28
  • 在線發(fā)布日期: 2023-11-27
  • 出版日期: 2023-11-22