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骨植入物納米多層結(jié)構(gòu)抗菌涂層研究進展
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作者單位:

1.上海理工大學(xué) 材料與化學(xué)學(xué)院;2.上海長海醫(yī)院 創(chuàng)傷骨科

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中圖分類號:

TG174.4

基金項目:

國家自然科學(xué)基金(51971148)


Research and Progress of Nano-multi-structured Antibacterial Coating for Bone Implants
Author:
Affiliation:

1.School of Materials and Chemistry,University of Shanghai for Science and Technology;2.Orthopedic trauma,Changhai Hospital of Shanghai

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    摘要:

    骨植入物表面負(fù)載納米多層結(jié)構(gòu)抗菌涂層具備多重優(yōu)勢，可以有效提高材料抗菌率，避免了使用抗生素產(chǎn)生細(xì)菌耐藥性的問題。相較于單層結(jié)構(gòu)涂層，納米多層結(jié)構(gòu)抗菌涂層同時具有骨植入物材料所需的多種性能，促進骨細(xì)胞的增殖與分化，有效降低細(xì)胞毒性所引起的不良反應(yīng)，是目前骨植入物表面涂層研究的重點。本文綜述了納米多層結(jié)構(gòu)抗菌涂層的研究進展，包括涂層的性能、制備方法及抗菌機制，討論了納米多層結(jié)構(gòu)抗菌涂層的發(fā)展方向，有望進一步解決細(xì)菌感染和骨整合等問題。

    Abstract:

    Nano-multi-structured antibacterial coatings on the surface of bone implants possess multiple advantages. They can effectively enhance the antibacterial rate of materials and prevent the bacterial resistance associated with antibiotic use. Compared with single-layer coatings, nano-multi-structured antibacterial coatings simultaneously provide various properties required for bone implants, promoting the proliferation and differentiation of bone cells while effectively reducing adverse reactions caused by cytotoxicity. Therefore, they are currently the focal point in research on surface coatings for bone implants. This article reviews the research progress of nano-multi-structured antibacterial coatings, including their performance, fabrication methods, and antibacterial mechanisms, and discusses the future directions of nano-multi-structured antibacterial coatings, which holds promise in addressing bacterial infections and bone integration.

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張鐠丹,馬 迅,劉 平,王靜靜,章 浩,李 偉.骨植入物納米多層結(jié)構(gòu)抗菌涂層研究進展[J].稀有金屬材料與工程,2023,52(12):4295~4306.[ZHANG Pudan, MA Xun, LIU Ping, WANG Jingjing, ZHANG Hao, LI Wei. Research and Progress of Nano-multi-structured Antibacterial Coating for Bone Implants[J]. Rare Metal Materials and Engineering,2023,52(12):4295~4306.]
DOI：10.12442/j. issn.1002-185X.20230307

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歷史
  • 收稿日期:2023-05-22
  • 最后修改日期:2023-06-27
  • 錄用日期:2023-07-04
  • 在線發(fā)布日期: 2023-12-29
  • 出版日期: 2023-12-22