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This paper mainly introduces several biomaterials with multi-layered porous structures and excellent mechanical properties in nature, and their macroscopic properties are closely related to the multi-layered micro-nanostructures on their surfaces. Through the construction of multi-layered porous structures, biomaterials not only greatly reduce their own density, but also often maintain excellent mechanical properties, such as light weight, high strength, sound absorption and noise reduction. Through the imitation of the porous structure of biomaterials, it is expected to provide important enlightenment and help for the development of artificial materials with biomimetic porous structure and excellent performance.