最新色国产精品精品视频,中文字幕日韩一区二区不卡,亚洲有码转帖,夜夜躁日日躁狠狠久久av,中国凸偷窥xxxx自由视频

+高級(jí)檢索
生物活性多孔鉭支架的構(gòu)建及其初步生物學(xué)評(píng)價(jià)
作者:
作者單位:

1.四川大學(xué)生物醫(yī)學(xué)工程學(xué)院;2.大連大學(xué)附屬中山醫(yī)院骨科研究中心

作者簡(jiǎn)介:

通訊作者:

中圖分類(lèi)號(hào):

基金項(xiàng)目:

國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目(2016YFC1102000、2016YFC1102003),中國(guó)博士后科學(xué)基金項(xiàng)目(2020M670715)


Construction and biological evaluation of bioactive porous tantalum scaffolds
Author:
Affiliation:

1.College of Biomedical Engineering,Sichuan University;2.Affiliated Zhongshan Hospital of Dalian University

Fund Project:

  • 摘要
  • |
  • 圖/表
  • |
  • 訪問(wèn)統(tǒng)計(jì)
  • |
  • 參考文獻(xiàn)
  • |
  • 相似文獻(xiàn)
  • |
  • 引證文獻(xiàn)
  • |
  • 資源附件
  • |
  • 文章評(píng)論
    摘要:

    表面生物活性涂層構(gòu)建是提升金屬內(nèi)植物骨整合能力的有效途徑,本研究利用電化學(xué)沉積技術(shù)在多孔鉭支架表面構(gòu)建生物活性羥基磷灰石(HA)涂層。通過(guò)接觸角和比表面積測(cè)試發(fā)現(xiàn),HA涂層的構(gòu)建顯著提升了多孔鉭表面親水性,并增加了其比表面積。利用模擬體液浸泡試驗(yàn)評(píng)估支架生物活性,發(fā)現(xiàn)僅浸泡3天后,多孔鉭支架表面就已被類(lèi)骨磷灰石沉積所覆蓋。建成骨細(xì)胞培養(yǎng)模型,通過(guò)激光共聚焦觀察及細(xì)胞增殖測(cè)試發(fā)現(xiàn),所有支架均具有良好的細(xì)胞相容性。并且,細(xì)胞共培養(yǎng)5天后,HA涂層化多孔鉭支架表面細(xì)胞的增殖率分別是未改性材料組和空白對(duì)照組的1.1和1.4倍,呈現(xiàn)了更大的促細(xì)胞增殖潛力。本研究中所制備的生物活性多孔鉭支架具備快速誘導(dǎo)類(lèi)骨磷灰石沉積能力,能夠促進(jìn)成骨細(xì)胞在其表面的貼附和增殖,在骨修復(fù)領(lǐng)域具有較大的臨床應(yīng)用前景。

    Abstract:

    The construction of surface bioactive coating is an effective way to improve the osseointegration ability of metal-based implants. In this study, bioactive hydroxyapatite (HA) coating was fabricated on the surface of porous tantalum (Ta) scaffolds by electrochemical deposition method. The construction of HA coating significantly enhanced the hydrophilicity of porous Ta and increased its specific surface area. The in vitro bioactivity evaluation via simulated body fluid immersion confirmed that the surface of HA coated scaffold was covered with bone-like apatite layer after 3 days of soaking. The in vitro cell culture using MC3T3-E1 cells showed that all porous tantalum scaffolds had good cytocompatibility. After culturing for 5 days, the proliferation rate of the bioactive porous Ta scaffold was 1.1 and 1.4 fold significantly higher than that of the unmodified porous Ta and control groups, respectively, suggesting greater potential on promoting cell adhesion and proliferation. The bioactive porous tantalum scaffold could rapidly induce the deposition of bone-like apatite and promote the attachment and proliferation of osteoblasts on its surface, suggesting its great clinical application prospect in the fields of bone repair.

    參考文獻(xiàn)
    相似文獻(xiàn)
    引證文獻(xiàn)
引用本文

劉聘,袁波,肖占文,謝輝,朱向東,張興棟.生物活性多孔鉭支架的構(gòu)建及其初步生物學(xué)評(píng)價(jià)[J].稀有金屬材料與工程,2022,51(1):225~231.[Pin Liu, Bo Yuan, Zhanwen Xiao, Hui Xie, Xiangdong Zhu, Xingdong Zhang. Construction and biological evaluation of bioactive porous tantalum scaffolds[J]. Rare Metal Materials and Engineering,2022,51(1):225~231.]
DOI:10.12442/j. issn.1002-185X.20210035

復(fù)制
文章指標(biāo)
  • 點(diǎn)擊次數(shù):
  • 下載次數(shù):
  • HTML閱讀次數(shù):
  • 引用次數(shù):
歷史
  • 收稿日期:2021-01-13
  • 最后修改日期:2021-02-18
  • 錄用日期:2021-03-22
  • 在線發(fā)布日期: 2022-02-09
  • 出版日期: 2022-01-28