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氟轉(zhuǎn)化處理AZ31B鎂合金冠脈支架的血液相容性
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1.昆明理工大學(xué) 材料科學(xué)與工程學(xué)院，云南 昆明 650093;2.中國(guó)科學(xué)院金屬研究所，遼寧 沈陽(yáng) 110016

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Undergraduate Training Programs for Innovation and Entrepreneurship (201910674006)


Hemocompatibility of Fluoride Treated AZ31B Magnesium Alloys Used for Intravascular Stents
Author:
Affiliation:

1.Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China;2.Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China

Fund Project:

Undergraduate Training Programs for Innovation and Entrepreneurship (201910674006)

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    摘要:

    基于鎂及鎂合金優(yōu)異的生物降解性、生物相容性和綜合力學(xué)性能，對(duì)鎂合金在血管支架領(lǐng)域的應(yīng)用進(jìn)行了探索。采用轉(zhuǎn)化處理在AZ31B鎂合金表面成功制備出氟轉(zhuǎn)化涂層；隨后分別采用溶血實(shí)驗(yàn)、凝血試驗(yàn)和血小板黏附試驗(yàn)研究了氟轉(zhuǎn)化處理后的AZ31B鎂合金的血液相容性能；為了分析其血液相容性能的機(jī)制，同時(shí)開展了材料表面能的測(cè)定。結(jié)果表明，氟轉(zhuǎn)化處理AZ31B鎂合金在冠脈介入治療領(lǐng)域極具應(yīng)用潛力。

    Abstract:

    Due to the excellent biodegradability, biocompatibility and mechanical properties of magnesium alloy, the possibility of magnesium alloy as intravascular stent was studied. Firstly, based on our previous work, a compact fluoride conversion coating was prepared on the surface of AZ31B magnesium alloy. The hemolytic tests, blood coagulation tests and platelet adhesion tests were carried out to evaluate the hemocompatibility of the fluoride treated AZ31B magnesium alloy. The surface energy was measured to analyze the mechanism of the hemocompatibility of the samples. Results show that the fluoride treated AZ31B magnesium alloy has potential application value in intravascular stenting.

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顏廷亭,栗可心,蔣志敏,苗忻怡,李潘,陳慶華,譚麗麗,楊柯.氟轉(zhuǎn)化處理AZ31B鎂合金冠脈支架的血液相容性[J].稀有金屬材料與工程,2022,51(2):469~473.[Yan Tingting, Li Kexin, Jiang Zhimin, Miao Xinyi, Li Pan, Chen Qinghua, Tan Lili, Yang Ke. Hemocompatibility of Fluoride Treated AZ31B Magnesium Alloys Used for Intravascular Stents[J]. Rare Metal Materials and Engineering,2022,51(2):469~473.]
DOI：10.12442/j. issn.1002-185X.20200932

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  • 收稿日期:2020-12-03
  • 最后修改日期:2021-01-06
  • 錄用日期:2021-02-04
  • 在線發(fā)布日期: 2022-03-03
  • 出版日期: 2022-02-28