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溶膠-凝膠法制備鈦基生物相容性MgO膜
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上海第十人民醫(yī)院，同濟大學附屬第十人民醫(yī)院,大連醫(yī)科大學附屬第一醫(yī)院,解放軍總醫(yī)院第一附屬醫(yī)院，北京市骨科植入醫(yī)療器械工程技術(shù)研究中心,解放軍總醫(yī)院第一附屬醫(yī)院，北京市骨科植入醫(yī)療器械工程技術(shù)研究中心,西安交通大學生命科學與技術(shù)學院生物醫(yī)學信息工程教育部重點實驗室,西安交通大學生命科學與技術(shù)學院生物醫(yī)學信息工程教育部重點實驗室

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Biocompatible MgO film on titanium substrate prepared by sol-gel method
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First Affiliated Hospital of Dalian Medical University,,Department of Orthopaedics,First Affiliated Hospital of Dalian Medical University;Department of Orthopaedics,First Affiliated Hospital of Dalian Medical University,Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University,Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University

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    摘要:

    植入物的表面修飾對于獲得生物相容性或功能性界面非常重要。本項研究中， 鈦金屬表面的MgO薄膜在400?C進行溶膠-凝膠化，觀察其微觀結(jié)構(gòu)、生物活性、抗菌性能和細胞毒性。結(jié)果發(fā)現(xiàn)，MgO在空氣中老化后轉(zhuǎn)化為Mg（OH）2。掃描電鏡觀察薄膜無裂紋。在模擬體液試驗中顯示出良好的生物活性，與成骨細胞有良好的相容性，對大腸桿菌有輕微的抗菌作用。MgO薄膜在鈦金屬生物醫(yī)學植入物表面改性中具有潛在的應用前景。

    Abstract:

    Surface modification of implant substrate is very important to obtain a biocompatible or functional interface. In this work, MgO film was sol-gel prepared on titanium substrate by sintering at 400 ?C. Microstructure, bioactivity, cytotoxicity and antibacterial property of the obtained film were investigated. It was found that MgO converted to Mg(OH)2 after ageing in air. The film was crack free observed by scanning electron microscopy. It was bioactive in the simulated body fluid test, biocompatible with osteoblast cells and slightly antibacterial against E. Coli. The MgO film would have potential application in surface modification of biomedical titanium implants.

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虞舜志,李忠海,韓麗偉,趙彥濤,Zafer Alajmi,付濤.溶膠-凝膠法制備鈦基生物相容性MgO膜[J].稀有金屬材料與工程,2018,47(9):2663~2667.[yushunzhi, lizhonghai, hanliwei, zhaoyantao, Zafer Alajmi, FuTao. Biocompatible MgO film on titanium substrate prepared by sol-gel method[J]. Rare Metal Materials and Engineering,2018,47(9):2663~2667.]
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  • 收稿日期:2017-02-13
  • 最后修改日期:2018-01-03
  • 錄用日期:2018-01-03
  • 在線發(fā)布日期: 2018-11-01
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