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植酸改性對(duì)齒科純鈦SLA表面生物活性的影響
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南京航空航天大學(xué),南京航空航天大學(xué),南京航空航天大學(xué),南京航空航天大學(xué),江蘇省口腔醫(yī)院,江蘇省口腔醫(yī)院

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中央高?；究蒲袠I(yè)務(wù)費(fèi)項(xiàng)目(NP2012303)；江蘇高校優(yōu)勢(shì)學(xué)科建設(shè)工程資助項(xiàng)目


Effect of bioactivity on medical titanium SLA surface after modification of phytic acid
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Nanjing University of Aeronautics and Astronautics,Nanjing University of Aeronautics and Astronautics,Nanjing University of Aeronautics and Astronautics,Nanjing University of Aeronautics and Astronautics,Stomatological Hospital of Jiangsu Province,Stomatological Hospital of Jiangsu Province

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A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions

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    摘要:

    采用植酸對(duì)純鈦SLA表面進(jìn)行改性處理，然后在模擬體液（SBF）中礦化，研究植酸改性對(duì)SLA表面生物活性的影響。通過SEM、EDS和接觸角測(cè)試等檢測(cè)方法表征樣品的微觀形貌、元素組成和潤濕性。探討人骨髓間充質(zhì)干細(xì)胞（hBMSCs）在不同表面的增殖、粘附和分化行為。結(jié)果表明：植酸改性SLA表面接觸角為0°，為超親水表面；植酸改性處理提高了SLA表面誘導(dǎo)磷灰石沉積的能力；植酸改性SLA表面可以增加細(xì)胞的增殖、粘附和分化，提高SLA表面的生物活性。 關(guān)鍵詞：純鈦、植酸、表面改性、生物活性、超親水性

    Abstract:

    In this research, the effect of phytic acid on bioactivity of the surface of SLA-titanium was studied, through modification with phytic acid and subsequent mineralization in the simulated body fluid (SBF). The microstructure, chemical properties and wettability was demonstrated, using SEM、EDS and contact angle analysis. Human bone marrow stromal cells (hBMSCs) were cultured on different surfaces to investigate the proliferation, adhesion and differentiation. The results demonstrate that the contact angle of surface modified with phytic acid is 0°, which means it is superhydrophilicity. The ability to induce apatite deposition, as well as the proliferation, adhesion differentiation of cells are improved obviously on SLA-surface, which reflect a better bioactivation treatment as a result of using phytic acid solution.

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錢海梅,汪濤,張嘉敏,繆潤杰,湯春波,湯易.植酸改性對(duì)齒科純鈦SLA表面生物活性的影響[J].稀有金屬材料與工程,2017,46(12):3832~3837.[qianhaimei, wangtao, zhangjiamin, miaorunjie, tangchunbo, tangyi. Effect of bioactivity on medical titanium SLA surface after modification of phytic acid[J]. Rare Metal Materials and Engineering,2017,46(12):3832~3837.]
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  • 收稿日期:2016-10-10
  • 最后修改日期:2017-02-13
  • 錄用日期:2017-02-20
  • 在線發(fā)布日期: 2018-01-04
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