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鈦酸鹽納米線控制細(xì)胞的粘附及其活性
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南方醫(yī)科大學(xué)附屬口腔醫(yī)院廣東省口腔醫(yī)院種植中心,廣州醫(yī)科大學(xué)第一附屬醫(yī)院口腔科,南方醫(yī)科大學(xué)附屬口腔醫(yī)院廣東省口腔醫(yī)院種植中心,南方醫(yī)科大學(xué)附屬口腔醫(yī)院廣東省口腔醫(yī)院種植中心,南方醫(yī)科大學(xué)附屬口腔醫(yī)院廣東省口腔醫(yī)院種植中心,南方醫(yī)科大學(xué)附屬口腔醫(yī)院廣東省口腔醫(yī)院種植中心,南方醫(yī)科大學(xué)附屬口腔醫(yī)院廣東省口腔醫(yī)院種植中心,南方醫(yī)科大學(xué)附屬口腔醫(yī)院廣東省口腔醫(yī)院種植中心,南方醫(yī)科大學(xué)附屬口腔醫(yī)院廣東省口腔醫(yī)院種植中心

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國家自然科學(xué)基金資助(項(xiàng)目號81170998)廣東省醫(yī)學(xué)科學(xué)技術(shù)研究基金資助(項(xiàng)目號201512121535549)


Investigation of Cell Adhesion and Activity Controlled by Titanate Nanowire
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Center of Oral Implantology Guangdong Provincial Stomatological Hospital,SouthernMedical University,Guangzhou,Stomotology Department of the First Affiliated Hospital of Guang Zhou Medical University,Guangzhou,Center of Oral Implantology Guangdong Provincial Stomatological Hospital,SouthernMedical University,Guangzhou,Center of Oral Implantology Guangdong Provincial Stomatological Hospital,SouthernMedical University,Guangzhou,Center of Oral Implantology Guangdong Provincial Stomatological Hospital,SouthernMedical University,Guangzhou,Center of Oral Implantology Guangdong Provincial Stomatological Hospital,SouthernMedical University,Guangzhou,Center of Oral Implantology Guangdong Provincial Stomatological Hospital,SouthernMedical University,Guangzhou,Center of Oral Implantology Guangdong Provincial Stomatological Hospital,SouthernMedical University,Guangzhou,Center of Oral Implantology Guangdong Provincial Stomatological Hospital,SouthernMedical University,Guangzhou

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    摘要:

    控制細(xì)胞與生物材料的互動在植入器械包括藥物輸送系統(tǒng)，生物感應(yīng)器等方面的應(yīng)用是非常渴望的。目前我們對于開發(fā)能夠限制細(xì)胞的粘附以及活性的新材料有著較大的期待。在本實(shí)驗(yàn)中我們通過水熱法在鈦片表面制作鈦酸鹽納米線支架，研究了鈦酸鹽納米線對于MG63成骨細(xì)胞粘附、增殖、分化的影響。結(jié)果顯示與光滑組鈦片比較在納米線表面有較少的細(xì)胞粘附，掃描電鏡觀察可見僅有少量細(xì)胞被納米線穿刺并固定在納米線表面，并且細(xì)胞形態(tài)呈不規(guī)則的長條形，免疫熒光染色顯示細(xì)胞不能形成細(xì)胞骨架并且細(xì)胞形狀不規(guī)則；隨后的細(xì)胞增殖也受到了明顯的抑制；堿性磷酸酶以及RUNX2活性檢測發(fā)現(xiàn)納米線組細(xì)胞其分化能力也相應(yīng)減弱。結(jié)論，在納米線表面細(xì)胞早期粘附以及增殖及分化功能受到嚴(yán)重抑制。這種抗細(xì)胞粘附的納米結(jié)構(gòu)在藥物緩釋系統(tǒng)以及生物感應(yīng)器等方面有應(yīng)用的價值。

    Abstract:

    There’s no dispute that the control of interaction between cell and implant which includes drug delivery system and biosensor is a long-purchased goal. Recently, scientists are looking forward to exploring new materials in restricting cell adhesion and activity. In this essay, titanate tanowire was formed on the surface of titanium disks by hydrothermal route and the interaction between titanate tanowire and MG63 osteoblasts(including cell adhesion, proliferation and differentiation)was investigated. It’s shown that fewer cells were adhered on the smooth titanium disks rather than the nanowire one. Only a few cells were fixed on the tanowire surface which showed an irregular long spindle shape observed by SEM. Immunofluoresense also illustrated an irregular cell shape without forming a cell structure, the proliferation was restricted at the same time. Meanwhile, alkaline phosphatase and RUNX2 activity test shared the same results. It can be well concluded that cell adhesion and activity was seriously restricted titanate nanowire surface, such results can be applied on the further studies of drug delivery system and biosensor.

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丁祥龍,王敬旭,林曦,吳靖漪,岳新新,賈芳,郭澤紅,高巖,周磊.鈦酸鹽納米線控制細(xì)胞的粘附及其活性[J].稀有金屬材料與工程,2017,46(11):3394~3399.[Xianglong Ding, Jingxu Wang, Xi Lin, Jingyi Wu, Xinxin Yue, Fang Jia, Zehong Guo, Yan Gao, Lei Zhou. Investigation of Cell Adhesion and Activity Controlled by Titanate Nanowire[J]. Rare Metal Materials and Engineering,2017,46(11):3394~3399.]
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  • 收稿日期:2015-09-17
  • 最后修改日期:2016-01-15
  • 錄用日期:2016-02-24
  • 在線發(fā)布日期: 2017-12-13
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