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多孔鈦骨組織工程支架設(shè)計及孔結(jié)構(gòu)表征
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四川大學(xué),四川大學(xué),四川大學(xué),競升醫(yī)療技術(shù)服務(wù)有限公司,四川大學(xué),四川大學(xué),四川大學(xué),四川大學(xué)

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中圖分類號:

TG；TH164

基金項(xiàng)目:

國家自然科學(xué)基金青年基金（51205265），四川省科技支撐計劃項(xiàng)目（2015GZ0012）, 國家科技支撐計劃項(xiàng)目（2012BAI17B01)，973計劃項(xiàng)目(2011CB606201)，國家自然科學(xué)基金重大項(xiàng)目(81190131)


Design and Charaterization of Porous Titanium Scaffold for Bone Tissue Engineering
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Affiliation:

Sichuan University,Sichuan University,Jing Sheng Medical Technology Services LTD,,,Sichuan University,Sichuan University

Fund Project:

Fund of Guangxi Key Laboratory of Environmental Engineering, Protection and Assessment (0802Z014); Fund of Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection, Ministry of Education, China (ERESEPZ15)

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    摘要:

    針對目前骨組織工程支架微孔結(jié)構(gòu)難以準(zhǔn)確設(shè)計制備，提出了一種基于點(diǎn)云的參數(shù)化建模 3D打印新方法。通過提取Cube（C）、Diamond(D)、Gyriod(G)三種結(jié)構(gòu)的型面函數(shù)點(diǎn)云數(shù)據(jù)，完成對不同孔結(jié)構(gòu)特征的參數(shù)化建模。通過對模型有限元力學(xué)分析，對不同孔結(jié)構(gòu)特征的多孔鈦骨組織支架進(jìn)行力學(xué)設(shè)計與訂制。借助激光選區(qū)熔融（SLM）3D打印技術(shù)，完成對不同孔特征的骨組織支架快速成型。對多孔鈦組織支架進(jìn)行了相關(guān)材料學(xué)表征，包括孔結(jié)構(gòu)表征與力學(xué)性能測試。結(jié)果表明：參數(shù)化模型的快速成型制造，能夠有效地設(shè)計制備鈦合金骨組織工程支架的孔結(jié)構(gòu)特性，且可有效設(shè)計訂制支架的機(jī)械性能，從仿生的角度實(shí)現(xiàn)多孔鈦合金骨組織工程支架生物學(xué)功能的設(shè)計優(yōu)化。

    Abstract:

    In order to fabricate bone tissue engineering scaffold accurately, a novel method that combines parametric modeling and 3D printing was proposed. In this method, the scaffold structures were designed using cloud data of molded surface. Firstly, the cloud data containing the surface information of Cube structure, Diamond structure and Gryriod structure were obtained. Then the scaffold structures with different parameters were expressed by mathematical functions. After that, finite element analysis was done to the scaffolds. The mechanical properties of porous scaffolds were calculated based on finite element analysis. Bone tissue engineering scaffolds with differentSporous structures were manufactured by 3D printing. Finally, characterizations of printed titanium scaffolds were done to detect the porosity and mechanical properties. The results show that the parameterized model and rapid prototyping manufacturing can design and fabricate titanium alloy scaffolds with specific pore structure characteristics effectively. And the scaffold"s mechanical properties can be also designed. It realized porous titanium alloy scaffolds with optimized biological functions from the perspective of bionics.

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鄧珍波,周長春,樊渝江,彭京平,朱向東,裴玄,殷國富,張興棟.多孔鈦骨組織工程支架設(shè)計及孔結(jié)構(gòu)表征[J].稀有金屬材料與工程,2016,45(9):2287~2292.[Deng Zhenbo, zhouchangchun, Fan Yujiang, Peng Jingping, Zhu Xiangdong, Pei Xuan, Yin Guofu, Zhang Xingdong. Design and Charaterization of Porous Titanium Scaffold for Bone Tissue Engineering[J]. Rare Metal Materials and Engineering,2016,45(9):2287~2292.]
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  • 收稿日期:2015-09-10
  • 最后修改日期:2016-04-05
  • 錄用日期:2016-04-26
  • 在線發(fā)布日期: 2016-10-09
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