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粉末冶金制備TNZS基生物材料的體外組織相容性
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江蘇大學(xué) 先進(jìn)制造與現(xiàn)代裝備技術(shù)工程研究院,江蘇大學(xué) 先進(jìn)制造與現(xiàn)代裝備技術(shù)工程研究院,江蘇大學(xué) 先進(jìn)制造與現(xiàn)代裝備技術(shù)工程研究院

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江蘇省高校自然科學(xué)基金重大項目(11KJA430004)、江蘇大學(xué)拔尖人才工程基金(1211110001)


Histocompatibility in vitro of TNZS-based biomaterials prepared by powder metallurgy
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    摘要:

    采用高能球磨與冷壓燒結(jié)相結(jié)合的粉末冶金法制備了TNZS、TiO2/TNZS及HA/TNZS生物鈦基材料,并評價了三者的體外組織相容性。研究表明：三種TNZS基生物材料均無細(xì)胞毒性；TiO2/TNZS和HA/TNZS表面在1 d、3 d、5 d和7 d的細(xì)胞相對增殖抑制率CPIR值大幅低于TNZS組,TiO2和HA的添加顯著提高了TNZS材料表面的細(xì)胞增殖速度,增強(qiáng)了其細(xì)胞增殖能力,更有助于誘導(dǎo)成骨細(xì)胞的體外增殖；三種TNZS基材料表面貼附的成骨細(xì)胞偽足伸展?fàn)顟B(tài)良好,而TiO2/TNZS表面貼附的成骨細(xì)胞分布更加均勻。

    Abstract:

    TNZS, TiO2/TNZS and HA/TNZS bio-medical materials were prepared by powder metallurgy comebining high-energy milling with cold pressed sintering. Histocompatibility in vitro of the three TNZS-based materials were studied. The results show that: three materials have no cytotoxicity, meeting toxicity safety requirements of implant materials; CPIR on the surface of TiO2/TNZS and HA/TNZS for 1 d, 3 d, 5 d and 7 d have significantly lower than that of TNZS group, showing that the addition of TiO2 and HA can improve the speed of cell proliferation on the surface of TNZS material and have better induction of proliferation of osteoblasts in vitro; the distribution of osteoblasts attached to the surface of TiO2/TNZS has more uniform; pseudopodium extension of osteoblasts attached to the surface of three materials are in good condition.

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朱利華,吳劉軍,許曉靜.粉末冶金制備TNZS基生物材料的體外組織相容性[J].稀有金屬材料與工程,2017,46(9):2601~2606.[zhu li hua, Wu Liu jun, Xu xiao jing. Histocompatibility in vitro of TNZS-based biomaterials prepared by powder metallurgy[J]. Rare Metal Materials and Engineering,2017,46(9):2601~2606.]
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  • 收稿日期:2015-04-23
  • 最后修改日期:2015-10-28
  • 錄用日期:2015-11-18
  • 在線發(fā)布日期: 2017-11-29
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