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醫(yī)用金屬材料離子釋放機(jī)制、致病機(jī)理及防護(hù)
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北京有色金屬研究總院創(chuàng)新基金 (20120301)


Metal Ions Release Mechanism from Metallic Biomaterials and Their Pathogenic Mechanism and Protection
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    摘要:

    結(jié)合近年來國內(nèi)外醫(yī)用鈦合金等金屬材料在生物體和人體臨床應(yīng)用研究成果，研究了人體植入物等醫(yī)用金屬材料中Ni、Al、V等有害離子的釋放機(jī)制、致病機(jī)理及防護(hù)（涂層）方法。系統(tǒng)分析了常用醫(yī)用金屬材料Ti6Al4V和TiNi形狀記憶合金等鈦合金在腐蝕等作用下有害離子的釋放機(jī)制，有害離子及其形成化合物對人體的毒性作用，和常用表面改性技術(shù)制備涂層對于有害離子的抑制和防護(hù)作用。研究結(jié)果表明，近年來發(fā)展起來的表面改性技術(shù)顯著提高鈦合金耐蝕性，可以有效抑制有害離子的釋放，提高鈦合金的生物相容性

    Abstract:

    Based on the research and development of titanium alloys for biomedical applications in China and abroad during the past few years, the metal ions release mechanism from titanium-based alloys, and their pathogenic mechanism and protective coatings and measurements were investigated. A systematic analysis is made of the effect of the corrosion on the metal ions release mechanism from the Ti6Al4V alloy and TiNi shape memory alloy, of the relationship of metal ions with pathogenic mechanism of some diseases, and of the protective coatings and surface modification techniques inhibiting the release of the metal ions. It shows that a large number of surface modification techniques were developed in recent years to improve the biocompatibility and corrosion resistance of titanium alloys and the release of metal ions were inhibited

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王勝難,崔 躍,袁志山,李君濤,繆衛(wèi)東,王江波,朱 明.醫(yī)用金屬材料離子釋放機(jī)制、致病機(jī)理及防護(hù)[J].稀有金屬材料與工程,2015,44(2):509~513.[Wang Shengnan, Cui Yue, Yuan Zhishan, Li Juntao, Miao Weidong, Wang Jiangbo, Zhu Ming. Metal Ions Release Mechanism from Metallic Biomaterials and Their Pathogenic Mechanism and Protection[J]. Rare Metal Materials and Engineering,2015,44(2):509~513.]
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  • 收稿日期:2014-02-10
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  • 在線發(fā)布日期: 2015-05-29
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