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鎂合金支架材料AZ81表面PLGA(PTX)/PLLA/MAO涂層的研究
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國家自然科學(xué)基金青年科學(xué)基金資助 (51301117)；山西省青年科技研究基金資助 (2013021003-1, 2013021014-2)


PLGA(PTX)/PLLA/MAO Coating on the Surface of AZ81 Magnesium Alloy Stent Materials
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    摘要:

    在AZ81鎂合金表面制備了抗腐蝕和藥物釋放復(fù)合涂層，并對其耐蝕性、藥物釋放性能及生物相容性進(jìn)行研究。DSC和紅外光譜數(shù)據(jù)表明，紫杉醇均勻分散在PLGA體系中。藥物釋放數(shù)據(jù)表明30 d后，藥物釋放率在80%左右。SEM、電化學(xué)阻抗、極化及鎂離子釋放數(shù)據(jù)表明，PLLA涂層通過有效填充微弧氧化膜表面的微孔與裂縫提高了鎂合金的耐腐蝕性。血液和細(xì)胞實(shí)驗(yàn)表明涂層鎂合金血液相容性良好，無細(xì)胞毒性

    Abstract:

    A composite coating was prepared to control drug release and corrosion of magnesium alloys stent materials AZ81, and the corrosion resistance, drug release and biocompatibility were investigated. IR spectrum and DSC results show that paclitaxel can be evenly dispersed in the PLGA. The drug-release curves indicate that the cumulative release rate after 30 d reaches approximately 80%. SEM, the electrochemical impedance spectroscopy, polarization curve and magnesium release results suggest that the PLLA coating improve the corrosion resistance by preventing the corrosive ions from diffusing to the magnesium substrate. The blood and cell test results reveal that the samples have good hemocompatibility and no cytotoxicity

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郭美卿,黃 棣,戴 震,許鑫華,陳維毅.鎂合金支架材料AZ81表面PLGA(PTX)/PLLA/MAO涂層的研究[J].稀有金屬材料與工程,2015,44(2):412~418.[Guo Meiqing, Huang Di, Dai Zhen, Xu Xinhua, Chen Weiyi. PLGA(PTX)/PLLA/MAO Coating on the Surface of AZ81 Magnesium Alloy Stent Materials[J]. Rare Metal Materials and Engineering,2015,44(2):412~418.]
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  • 收稿日期:2014-02-21
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  • 在線發(fā)布日期: 2015-05-29
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