2-HA生物陶瓷膜層"/> 2與TiO2-HA生物陶瓷膜層,通過(guò)溶血率實(shí)驗(yàn)、動(dòng)態(tài)凝血時(shí)間實(shí)驗(yàn)和血小板黏附實(shí)驗(yàn)等方面評(píng)價(jià)其血液相容性。研究結(jié)果表明：各試樣的溶血率都遠(yuǎn)小于5%,均符合醫(yī)用材料的溶血率要求,不會(huì)產(chǎn)生溶血作用。與鈦基TiO2生物陶瓷膜層和鈦基材相比,鈦基TiO2-HA生物陶瓷膜層的溶血率更低,動(dòng)態(tài)凝血時(shí)間曲線變化更為緩慢,黏附的血小板更少,且變形程度更輕,具有更好的抑制血小板的聚集與變形的性能,血液相容性更優(yōu)。"/>

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鈦基表面TiO2-HA生物陶瓷膜層的血液相容性研究
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江蘇大學(xué)機(jī)械工程學(xué)院,常州大學(xué),江蘇大學(xué)機(jī)械工程學(xué)院,江蘇大學(xué)實(shí)驗(yàn)動(dòng)物中心,江蘇大學(xué)實(shí)驗(yàn)動(dòng)物中心

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R138

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江蘇省高校自然基金重大項(xiàng)目(11KJA430004),江蘇省高校自然基金(12KJD460002)項(xiàng)目(1291110038)資助


Blood Compatibility of TiO2-HA Bioceramic Coating on Titanium
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School of Mechanical Engineering,Jiangsu University,,School of Mechanical Engineering,Jiangsu University,Laboratory Animal Research CenterS,Jiangsu University,Laboratory Animal Research CenterS,Jiangsu University

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    摘要:

    采用微弧氧化法及微弧氧化-水熱法對(duì)純鈦進(jìn)行改性,制備了TiO2與TiO2-HA生物陶瓷膜層,通過(guò)溶血率實(shí)驗(yàn)、動(dòng)態(tài)凝血時(shí)間實(shí)驗(yàn)和血小板黏附實(shí)驗(yàn)等方面評(píng)價(jià)其血液相容性。研究結(jié)果表明：各試樣的溶血率都遠(yuǎn)小于5%,均符合醫(yī)用材料的溶血率要求,不會(huì)產(chǎn)生溶血作用。與鈦基TiO2生物陶瓷膜層和鈦基材相比,鈦基TiO2-HA生物陶瓷膜層的溶血率更低,動(dòng)態(tài)凝血時(shí)間曲線變化更為緩慢,黏附的血小板更少,且變形程度更輕,具有更好的抑制血小板的聚集與變形的性能,血液相容性更優(yōu)。

    Abstract:

    Modified titanium materials, including TiO2 and TiO2-HA bioceramic coatings, were prepared by micro-arc oxidation and micro-arc oxidation-hydro-thermal methods. Determination of the hemocompatibility of the coatings through a hemolysis experiment, dynamic clotting time test, and platelet adhesion experiment was also performed. The results demonstrated that: Hemolysis rates of all samples were less than 5%, no hemolysis was observed. Compared with titanium and TiO2 bioceramic coating of titanium, TiO2-HA bioceramic coating of titanium exhibited lower hemolysis rate, slower change in dynamic clotting time and less platelet adherence. The proposed TiO2-HA bioceramic coating further showed a lower degree of deformation, better inhibition of platelet aggregation and deformation, and excellent hemocompatibility.

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徐琳,丁建寧,許曉靜,何遠(yuǎn)清,雷小春.鈦基表面TiO2-HA生物陶瓷膜層的血液相容性研究[J].稀有金屬材料與工程,2017,46(5):1299~1304.[Xu Lin, Ding Jianning, Xu Xiaojing, HeYuanqing, Lei Xiaochun. Blood Compatibility of TiO2-HA Bioceramic Coating on Titanium[J]. Rare Metal Materials and Engineering,2017,46(5):1299~1304.]
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  • 收稿日期:2015-01-15
  • 最后修改日期:2015-03-06
  • 錄用日期:2015-05-13
  • 在線發(fā)布日期: 2017-09-27
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