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Modeling and Experimental Studies of Peeling of Polymer Coating for Biodegradable Magnesium Alloy Stents
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Modeling and Experimental Studies of Peeling of Polymer Coating for Biodegradable Magnesium Alloy Stents
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Fondazione CaRiTRO (2011.0250); Politecnico di Milano International Fellowships Program (PIF)

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    摘要:

    可降解鎂合金支架(MAS)能夠改善商用裸支架和藥物洗脫支架的長期治療效果。由于鎂合金支架在人體內(nèi)降解速度太快,限制了其對病變血管的支撐性能。保護性聚合物涂層為鎂合金支架提供了一種降低腐蝕速度的有效方法。然而,聚合物涂層在支架擴張時出現(xiàn)的剝離現(xiàn)象是阻礙其運用的一大障礙。在本研究中,分別運用有限元方法和實驗方法對一種優(yōu)化設計的鎂合金支架進行了聚合物涂層剝離問題的研究。首先通過90o剝離實驗測試,為粘聚區(qū)有限元模型提供了臨界能量釋放率,以此為基礎的90o剝離的模擬結(jié)果和實驗結(jié)果吻合良好。運用可靠的粘聚區(qū)模型參數(shù),支架-聚合物涂層有限元模型考察了支架在擴張過程中是否會發(fā)生涂層剝離現(xiàn)象。本研究為考察支架聚合物涂層剝離現(xiàn)象提供了一種簡單可靠的方法,為改善可降解鎂合金支架的聚合物涂層性能提出了相應的建議。

    Abstract:

    Biodegradable magnesium alloy stents (MAS) could improve the long-term clinical results of commercial bare metal or drug-eluting stents. MAS have shown a limited mechanical support for diseased vessels due to fast degradation. Protective polymer coating is a reasonable way to reduce the degradation rate of MAS. However, peeling of the coating during stent expansion is the main obstacle in stent application. In this study, experimental and computational methods were used to study the peeling problem of an optimized MAS design. The 90o peeling test provided the critical energy release rate with cohesive zone method to be used in the simulation study; the 90o peeling modeling had good agreement with the experimental test. Using reliable cohesive element material parameters, the simulation could verify whether the peeling happened when the coated MAS was expanded. The aim of this study is to provide an easy and reliable method to approach peeling problem of MAS, giving the instructions for the improvement of MAS coatings.

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吳 衛(wèi),Lorenza Petrini, Lina Altomare, Silvia Farè,Rosaria Tremamunno,于振濤,Francesco Migliavacca. Modeling and Experimental Studies of Peeling of Polymer Coating for Biodegradable Magnesium Alloy Stents[J].稀有金屬材料與工程,2014,43(12):2877~2822.[Wu Wei, Lorenza Petrini, Lina Altomare, Silvia Farè, Rosaria Tremamunno, Yu Zhentao, Francesco Migliavacca. Modeling and Experimental Studies of Peeling of Polymer Coating for Biodegradable Magnesium Alloy Stents[J]. Rare Metal Materials and Engineering,2014,43(12):2877~2822.]
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  • 收稿日期:2014-03-25
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  • 在線發(fā)布日期: 2015-04-16
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