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心血管支架用Mg-Nd-Zn-Zr生物可降解鎂合金的性能研究
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中國博士后科學基金(20100470030)；南京工程學院引進人才科研啟動基金項目(YKJ201201)


Performances of Biodegradable Mg-Nd-Zn-Zr Magnesium Alloy for Cardiovascular Stent
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    摘要:

    以Mg-3.13Nd-0.16Zn-0.41Zr（質量分數(shù)，%, JDBM）鎂合金為研究對象，研究擠壓態(tài)JDBM的細胞毒性和腐蝕性能。通過熱擠壓工藝制備出心血管支架用鎂合金微管，并觀察其組織。采用激光切割、電化學拋光等工藝制備出心血管支架，測試支架表面粗糙度和徑向支撐力。結果表明，JDBM鎂合金對內皮細胞無毒性，具有理想的耐蝕性能和腐蝕方式；制備出的心血管支架的徑向支撐力超過正常成年人血管收縮壓的4倍，滿足心血管支架對力學性能的要求。

    Abstract:

    Mg-3.13Nd-0.16Zn-0.41Zr (wt%, JDBM) alloy was chosen and the cell toxicity and corrosion property of the as-extruded JDBM were studied. Magnesium tube was prepared by hot extrusion processing and the microstructure of the tube was observed. The cardiovascular stent was prepared by laser cutting and electrochemical polishing processes. The surface roughness and radial expansion force were tested. The results show that JDBM magnesium alloy exhibits no cell toxicity of Endothelial cell, good corrosion resistance and corrosion mode. The radial expansion force of the prepared cardiovascular stents is over 4 times than that of the maximal vascular compression pressure of normal adult, which meets the requirement of the mechanical properties for cardiovascular stents.

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章曉波,毛 琳,袁廣銀,王章忠.心血管支架用Mg-Nd-Zn-Zr生物可降解鎂合金的性能研究[J].稀有金屬材料與工程,2013,42(6):1300~1305.[Zhang Xiaobo, Mao Lin, Yuan Guangyin, Wang Zhangzhong. Performances of Biodegradable Mg-Nd-Zn-Zr Magnesium Alloy for Cardiovascular Stent[J]. Rare Metal Materials and Engineering,2013,42(6):1300~1305.]
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  • 收稿日期:2012-06-10
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