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磷酸三鈣涂層鎂合金材料的體內(nèi)降解及組織相容性研究
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國(guó)家自然科學(xué)基金(30872724,81071460)


In Vivo Degradation and Biocompatibility of Magnesium Alloy Coated with Tricalcium Phosphate
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    摘要:

    探討新型醫(yī)用金屬材料磷酸三鈣(β-TCP)涂層鎂合金的體內(nèi)降解特性和生物活性,制備β-TCP涂層鎂合金(β-TCP-Mg-Al-Zn)并植入大鼠股骨骨髓腔,掃描電鏡觀察體內(nèi)植入材料的表面微觀結(jié)構(gòu)及材料表面能譜,分析材料表面鈣(Ca)和磷(P)元素的變化規(guī)律。結(jié)果表明,材料體內(nèi)植入1~4 w時(shí),(β-TCP)- Mg-Al-Zn材料表面有大量的粘附蛋白物質(zhì);材料體內(nèi)植入8 w時(shí),(β-TCP)- Mg-Al-Zn材料表面Ca和P元素含量明顯高于Mg-Al-Zn材料(P<0.05);體內(nèi)植入12 w時(shí),Mg-Al-Zn材料降解約33 %,而(β-TCP)-Mg-Al-Zn材料降解率為17 %。β-TCP涂層可有效地延緩Mg-Al-Zn鎂合金的體內(nèi)降解,并使Mg-Al-Zn材料表面具有良好的生物活性

    Abstract:

    The superficial degradation in vivo and biocompatibility of magnesium alloy (Mg-Al-Zn) coated with tricalcium phosphate (β-TCP) have been evaluated. (β-TCP)-Mg-Al-Zn implants were made and implanted into the femur of rats. The surface microstructure observation of implants and the EDS analysis were carried out. The changes of Ca and P on the surface of the implants were analyzed. Results show that many attachment proteins appear in the surface of (β-TCP)-Mg-Al-Zn after 4 weeks implantation. In the 8th week, the content of Ca and P in the surface of (β-TCP)-Mg-Al-Zn are higher than that in naked Mg-Al-Zn (P<0.05). In the 12th week, about 33 % of naked Mg-Al-Zn alloy is degraded, while 17 % of (β-TCP)-Mg-Al-Zn is degraded. β-TCP coating can decay the superficial degradation and improve the biocompatibility of Mg-Al-Zn matrix in vivo.

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趙 杰,郭 磊,付玉平,趙延剛,譚麗麗,楊 柯.磷酸三鈣涂層鎂合金材料的體內(nèi)降解及組織相容性研究[J].稀有金屬材料與工程,2013,42(5):1013~1016.[Zhao Jie, Guo Lei, Fu Yuping, Zhao Yan’gang, Tan Lili, Yang Ke. In Vivo Degradation and Biocompatibility of Magnesium Alloy Coated with Tricalcium Phosphate[J]. Rare Metal Materials and Engineering,2013,42(5):1013~1016.]
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  • 收稿日期:2012-05-16
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