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多孔磷酸鈣骨水泥與鈦合金支架材料修復(fù)兔顱骨骨缺損的比較研究
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國家自然科學(xué)基金（30730034）；國家教育部“十一五”科技項目（2006BAI02B03）


Comparison of Porous Calcium Acid Phosphate Cement and Titanium Alloy Scaffold in Repairing Skull Defect of Rabbits
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    摘要:

    通過采用結(jié)構(gòu)可控的多孔磷酸鈣骨水泥(calcium acid phosphate cement, CPC)和鈦合金支架材料修復(fù)兔顱骨骨缺損，比較了兩種修復(fù)材料骨環(huán)境下的成骨性能。結(jié)果顯示，與多孔鈦合金材料相比，多孔CPC材料表現(xiàn)出了更好的成骨活性。CPC材料的新生骨量、成骨速率均高于鈦合金材料。而且骨吸收重建過程也早于鈦合金材料。同時，三維貫通的孔隙結(jié)構(gòu)有利于骨組織的長入，能夠在一定程度上克服鈦合金材料的應(yīng)力屏蔽缺陷， 使植入體在早期獲得良好的固位, 從而使界面骨性結(jié)合得以順利進行。

    Abstract:

    The in vivo bone-regenerative capacity of porous calcium acid phosphate cement (CPC) and titanium alloy scaffold with controlled porous structure were investigated in rabbit calvarial defect models. The results show that the bone-regenerative capacity of porous CPC is much better than that of porous titanium alloy scaffold. Porous CPC exhibits more bone formation and higher mineralization appositional rate than porous titanium scaffold. Moreover, bone remolding of porous CPC is in earlier stage than that of porous titanium alloy scaffold. On the other hand, highly three-dimensional interconnected porous structure is beneficial for the growth of bone tissue. The mechanical properties of titanium alloy can be adapted to those of biological systems by applying a porous structure, which may enhance the integration process and improve implant fixation in earlier stage.

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白 峰,李國臣,劉 建,王 林,孟國林,桑宏勛.多孔磷酸鈣骨水泥與鈦合金支架材料修復(fù)兔顱骨骨缺損的比較研究[J].稀有金屬材料與工程,2010,39(11):1984~1988.[Bai Feng, Li Guochen, Liu Jian, Wang Lin, Meng Guolin, Sang Hongxun. Comparison of Porous Calcium Acid Phosphate Cement and Titanium Alloy Scaffold in Repairing Skull Defect of Rabbits[J]. Rare Metal Materials and Engineering,2010,39(11):1984~1988.]
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  • 收稿日期:2010-04-26
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