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近β生物鈦合金表面TiO2納米管結(jié)構(gòu)膜制備及其對成骨細(xì)胞生長的影響
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國家科技支撐項(xiàng)目（2007BAE07B05）；國家自然基金青年基金（50902115）


Fabrication of TiO2 Nanotube Array Film on Near-β Titanium Alloy and Its Effects on Osteoblast Growth
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    摘要:

    通過恒電位陽極氧化新型近β鈦合金Ti-5Zr-3Sn-5Mo-25Nb（TLM）制備具有不規(guī)則取向的TiO2納米管陣列膜。TiO2膜在SBF中可誘導(dǎo)磷灰石的沉積并形成HA，表明對成骨細(xì)胞早期附著無抑制作用，具有良好的細(xì)胞相容性。比較可見，在模擬體液浸泡3 d后，具有不規(guī)則取向的TiO2納米管陣列膜的TLM上成骨細(xì)胞附著率明顯高于具有TiO2納米管陣列的Ti片，并形成良好的細(xì)胞形態(tài)。說明陽極氧化進(jìn)一步改善了TLM鈦合金的生物相容性和生物活性，為植入體的早期愈合提供了條件。

    Abstract:

    Disordered-orientation TiO2 nanotube array films were prepared by constant-potential anodization of a novel near-β titanium alloy Ti-5Zr-3Sn-5Mo-25Nb (TLM). The TiO2 film can induce the deposition of the apatite to form HA in simulated body fluid (SBF), indicating that the film does not restrict early adhesion of the osteoblast and possesses good biocompatibility. By comparison, it is found that the adhesion ratio of osteoblast on TLM with disordered-orientation TiO2 nanotube array films after soaking in SBF for 3 d is obviously higher than that of Ti sheet with TiO2 nanotube arrays, and the cellular morphology is excellent. It is concluded that the anodization can further improve the biocompatibility and bioactivity of TLM titanium alloy.

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李廣忠,張文彥,韓建業(yè),張 健,康新婷,李亞寧.近β生物鈦合金表面TiO2納米管結(jié)構(gòu)膜制備及其對成骨細(xì)胞生長的影響[J].稀有金屬材料與工程,2010,39(7):1206~1209.[Li Guangzhong, Zhang Wenyan, Han Jianye, Zhang Jian, Kang Xinting, Li Yaning. Fabrication of TiO2 Nanotube Array Film on Near-β Titanium Alloy and Its Effects on Osteoblast Growth[J]. Rare Metal Materials and Engineering,2010,39(7):1206~1209.]
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  • 收稿日期:2010-02-08
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