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NiTi合金表面微觀形貌對血管內(nèi)皮細(xì)胞及血小板黏附的影響
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科技部國際科技合作重點(diǎn)項目(2004DFA06400); 國家自然基金項目(30970721)


Effects of Micropatterned Surface of NiTi Alloy on Adhesion of Endothelial Cells and Blood Platelets
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    摘要:

    主要探討血管支架材料——NiTi合金不同表面形貌對牛主動脈血管內(nèi)皮細(xì)胞及血小板黏附的影響。采用機(jī)械拋光、機(jī)械刻蝕和化學(xué)浸蝕的方法制備微孔、微凹槽等微結(jié)構(gòu)特征的NiTi合金表面。利用掃描電鏡、粗糙度輪廓儀等對材料表面微觀形貌和平均粗糙度進(jìn)行表征，并測定微孔和微凹槽的材料表面對血小板及血管內(nèi)皮細(xì)胞黏附的影響。結(jié)果表明：NiTi合金基體表面制備納米級粗糙度的微孔和微凹槽等不同微觀形貌對血小板黏附的影響不顯著，但可明顯促進(jìn)內(nèi)皮細(xì)胞的黏附；具有微孔結(jié)構(gòu)的材料表面黏附的細(xì)胞數(shù)量最多，且細(xì)胞生長狀態(tài)良好；材料表面微凹槽結(jié)構(gòu)對細(xì)胞的早期黏附具有接觸誘導(dǎo)效應(yīng)。微粗糙化的各種不同材料表面形貌對血小板黏附的影響不顯著

    Abstract:

    Effects of the surface morphology of micropatterned NiTi alloy, an intravascular stent material, on the adhesion of bovine aortic endothelial cells (BAECs) and blood platelets were investigated. Mechanical polishing, chemical pickling and sandpaper grinding were used to prepare NiTi alloy with micropores and microgrooves. The surface morphologies and average roughness (Ra) were characterized by SEM and surface profilometer. The effects of the material surface with micropores and microgrooves on the adhesion of blood platelets and endothelial cells were determined. Results show the NiTi alloy surface with micropores or microgrooves could be controlled in the range of nanometer. Both of these two micriopatterned surface could enhance BAECs adhesion, but the effect on platelet adhesion is not obvious; the number of BAECs adhesion on surface with micropores were significantly more than that on the surface with microgrooves. Furthermore, the cells in the surface with micropores show a good growth situation. The microgroove structure has contact-induction effect on the early adhesion of the cells

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沈 陽,王貴學(xué),張 勤,唐朝君,葛淑萍,俞青松. NiTi合金表面微觀形貌對血管內(nèi)皮細(xì)胞及血小板黏附的影響[J].稀有金屬材料與工程,2010,39(6):1018~1022.[Shen Yang, Wang Guixue, Zhang Qin, Tang Chaojun, Ge Shuping, Yu Qingsong. Effects of Micropatterned Surface of NiTi Alloy on Adhesion of Endothelial Cells and Blood Platelets[J]. Rare Metal Materials and Engineering,2010,39(6):1018~1022.]
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  • 收稿日期:2009-06-10
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