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316L不銹鋼血管內(nèi)支架表面Fe/Pd磁性膜的制備與生物學(xué)效應(yīng)
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Preparation and Biological Effect of Fe/Pd Magnetic Film on Vascular Stent Surface
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National Natural Science Foundation of China (30470486, 30770586); Chinese Key Foundation Research Project (2005CB623900)

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    摘要:

    以醫(yī)用316L不銹鋼血管支架為基體,采用電弧離子鍍技術(shù)在其表面制備Fe/Pd磁性薄膜。通過激光掃描共焦顯微鏡、數(shù)字磁通磁場測量儀分析薄膜的表面形貌、表面粗糙度及表面磁性膜支架的磁性能,并通過動物體內(nèi)實驗研究Fe/Pd磁性膜支架的生物學(xué)效應(yīng)。結(jié)果表明:Fe/Pd磁性膜支架表面光滑,并具有良好的生物學(xué)效應(yīng),顯著地促進了血管內(nèi)皮再生,同時有效地抑制了血管內(nèi)膜過度增生和血管壁的炎癥反應(yīng)

    Abstract:

    Fe/Pd magnetic films were prepared by vacuum arc ion plating technology on 316L stainless steel vascular stents. The surface morphology, the surface roughness and the magnetism of coated stents were characterized by laser scanning confocal microscope and digital magnetic flux and field measuring instruments, while the biological effects of the Fe/Pd coated magnetic stents were evaluated through animals experiment. The results show that the Fe/Pd coated magnetic stents, which are smooth and which have good biological compatibility, significantly promote vascular endothelium regeneration, and inhibit tunica intima thickening and vascular wall inflammatory

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麻西群,于振濤,胡 濤,余 森,皇甫強.316L不銹鋼血管內(nèi)支架表面Fe/Pd磁性膜的制備與生物學(xué)效應(yīng)[J].稀有金屬材料與工程,2010,39(6):949~952.[Ma Xiqun, Yu Zhentao, Hu Tao, Yu Sen, Huangfu Qiang. Preparation and Biological Effect of Fe/Pd Magnetic Film on Vascular Stent Surface[J]. Rare Metal Materials and Engineering,2010,39(6):949~952.]
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  • 收稿日期:2009-06-08
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