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醫(yī)用316L不銹鋼支架表面磁性膜對(duì)血管內(nèi)皮化的影響
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國(guó)家自然科學(xué)基金(30470486)；中國(guó)博士后科學(xué)基金面上資助金(20070410383)；中國(guó)博士后科學(xué)基金特別資助金(200801439


The Effect of Superficial Magnetic Films of 316L Medical Steel Stents on Endothelialization
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    摘要:

    研究了表面磁性膜醫(yī)用316L不銹鋼支架對(duì)血管內(nèi)皮化的影響。通過(guò)體外內(nèi)皮細(xì)胞培養(yǎng)和支架粘附內(nèi)皮細(xì)胞的實(shí)驗(yàn)來(lái)觀察體外支架內(nèi)皮化的情況；并通過(guò)動(dòng)物體內(nèi)支架植入實(shí)驗(yàn)觀察評(píng)價(jià)血管內(nèi)皮覆蓋及血小板粘附及激活情況。結(jié)果表明：表面磁性膜支架在體外可以促進(jìn)內(nèi)皮細(xì)胞的粘附、增殖，支架植入后在體內(nèi)可以促進(jìn)血管內(nèi)皮再生，加速支架內(nèi)皮化，同時(shí)抑制血小板粘附及激活

    Abstract:

    The effect of superficial magnetic film on vascular endothelialization for the 316L medical stainless steel stent was investigated in this study. The in vitro endothelial response of human umbilical vein endothelium cell (HUVECs) was investigated on the superficial magnetic film 316L medical stainless steel stent vs bare-metal stent surface；as well as the re-endothelialization and platelet adhesion reaction of superficial magnetic film 316L medical stainless steel stent vs bare-metal stent were evaluated with SEM after animal models implantation for 1 month and 3 months. The consequence indicates that the superficial magnetic film 316L medical stainless steel stent can increase the adhesion and proliferation of HUVECs in vitro，and promote the regenesis of vas endothelialization after implantation in vivo, as well as speed the stent endothelialization and inhibite the platelet adhesion reaction and activation, simultaneously

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胡 濤,于振濤,周 廉,介萬(wàn)奇,周景昱,王海昌.醫(yī)用316L不銹鋼支架表面磁性膜對(duì)血管內(nèi)皮化的影響[J].稀有金屬材料與工程,2009,38(9):1552~1555.[Hu Tao, Yu Zhentao, Zhou Lian, Jie Wanqi, Zhou Jingyu, Wang Haichang. The Effect of Superficial Magnetic Films of 316L Medical Steel Stents on Endothelialization[J]. Rare Metal Materials and Engineering,2009,38(9):1552~1555.]
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  • 收稿日期:2009-03-25
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