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CA-P/AZ31B鎂合金的生物相溶性研究
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國家自然科學(xué)基金資助項(xiàng)目(30500414)和遼寧省教育廳高等學(xué)?？茖W(xué)研究項(xiàng)目(05L508)


Biocompatibility of CA-P/AZ31B Magnesium Alloy
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    摘要:

    將具有磷酸鈣(CA-P)表面涂層的AZ31B鎂合金植入家兔的骨骼和肌肉組織間，觀察了體內(nèi)CA-P/AZ31B合金周圍骨骼、肌肉組織的炎性反應(yīng)，以及CA-P/AZ31B合金的微觀結(jié)構(gòu)，評(píng)價(jià)了CA-P/AZ31B合金的細(xì)胞毒性作用及溶血性。結(jié)果表明，CA-P涂層可有效地延緩AZ31B鎂合金降解產(chǎn)物的釋放速度，增加合金的表面粗糙度，減輕合金在體內(nèi)誘導(dǎo)的組織炎性反應(yīng)，顯著降低合金的溶血率。CA-P/AZ31B合金具有良好的生物相容性，有望成為新一代可降解生物醫(yī)學(xué)材料。

    Abstract:

    The AZ31B magnesium alloy coated with calcium phosphate (CA-P/AZ31B) was implanted in rabbit skeletal and muscular tissue in this study. The inflammatory reaction in skeletal and muscular tissue was observed around the magnesium alloy in vivo. The microstructure and cytotoxic effect of the magnesium alloy were detected. The results show that the release and degradation process of AZ31B magnesium alloy was efficiently delayed by coated with CA-P. The surface roughness of AZ31B magnesium alloy was raised by coated with CA-P, whereas the inflammation induced by AZ31B magnesium alloy was inhibited in vivo. By hemolysis tests, the hemolytic effect was significantly decreased for the CA-P/AZ31B magnesium alloy coated with CA-P. Therefore, the alloy would be a new generation of degradable and biocompatible materials for medical applications.

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郭 磊,劉 魁,張世亮,高曉宇,黃晶晶,楊 柯. CA-P/AZ31B鎂合金的生物相溶性研究[J].稀有金屬材料與工程,2009,38(1):99~103.[Guo Lei, Liu Kui, Zhang Shiliang, Gao Xiaoyu, Huang Jingjing, Yang Ke. Biocompatibility of CA-P/AZ31B Magnesium Alloy[J]. Rare Metal Materials and Engineering,2009,38(1):99~103.]
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  • 收稿日期:2008-01-27
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