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表面改性純鎂的細(xì)胞毒性和溶血率
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TG146.23

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重慶市科技攻關(guān)重大專項(xiàng)(CSPC,2004AA4003)


Biocompatibility of Magnesium after Surface Modification by Heat-Organic Films-Treatment
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    摘要:

    介紹了處理前后純鎂細(xì)胞毒性和溶血率試驗(yàn)的結(jié)果。試驗(yàn)結(jié)果表明,小鼠骨髓細(xì)胞與純鎂試樣直接接觸的細(xì)胞毒性實(shí)驗(yàn)中,純鎂沒有對(duì)小鼠骨髓細(xì)胞的增殖產(chǎn)生明顯的毒副作用;但未處理的純鎂試樣出現(xiàn)了嚴(yán)重的溶血現(xiàn)象。經(jīng)過(guò)熱-有機(jī)表面改性后,純鎂試樣的溶血率在生物材料允許的<5%的范圍之內(nèi)。本階段試驗(yàn)提示,經(jīng)表面改性后的純鎂可望用作生物材料。

    Abstract:

    Magnesium has almost the same density, elastic modulus and strength as human bone. In fact human body contains much more magnesium than titanium. The challenge of magnesium is to improve its corrosion and biocompatibility to body fluids while it is used as implants. This paper reports the results of a study in which untreated or treated magnesium samples were subjected to cyto-compatibility tests and hemolysis tests. The results show that no the change of cells morphological or inhibitory effect on cell growth were detected in the cyto-compatibility tests. In hemolysis tests, the untreated magnesium had hemolytic effect, whereas the hemolysis of heat-treated and heatorganic filmtreated samples is within the demand (<5%). Therefore, it is very possible to use magnesium and its alloys as hard tissue substitutes if their surface is properly modified.

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高家誠(chéng),李龍川,王勇,喬麗英.表面改性純鎂的細(xì)胞毒性和溶血率[J].稀有金屬材料與工程,2005,34(6):903~906.[Gao Jiacheng, Li Longchuan, Wang Yong, Qiao Liying. Biocompatibility of Magnesium after Surface Modification by Heat-Organic Films-Treatment[J]. Rare Metal Materials and Engineering,2005,34(6):903~906.]
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  • 最后修改日期:2004-07-28
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